Atopic dermatitis in children

Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children

Epidemiologic and preclinical data, and a small randomized trial in Boston, suggest that vitamin D supplementation may improve winter-related atopic dermatitis (AD). To determine the effect of vitamin D supplementation on winter-related AD. We performed a randomized, double-blind, placebo-controlled trial of Mongolian children with winter-related AD ( identifier: NCT00879424). Baseline eligibility included age 2 to 17 years, AD score 10 to 72 using the Eczema Area and Severity Index (EASI), and winter-related AD (eg, history of AD worsening during the fall-to-winter transition). Subjects were enrolled in Ulaanbaatar during winter and randomly assigned to oral cholecalciferol (1000 IU/day) versus placebo for 1 month. All children and parents received emollient and patient education about AD and basic skincare. The main outcomes were changes in EASI score and in the Investigator’s Global Assessment. The 107 enrolled children had a mean age of 9 years (SD 5), and 59% were male. Their median age of AD onset was 3 months (interquartile range 2 months to 1 year) and mean EASI score at baseline 21 (SD 9). One-month follow-up data were available for 104 (97%) children. Compared with placebo, vitamin D supplementation for 1 month produced a clinically and statistically significant improvement in EASI score (adjusted mean change: −6.5 vs −3.3, respectively; P = .04). Moreover, the change in the Investigator’s Global Assessment favored vitamin D over placebo (P = .03). There were no adverse effects in either group.

Vitamin D supplementation improved winter-related AD among Mongolian children, a population likely to have vitamin D deficiency in winter.

Writer:Carlos A.CamargoJr.MD, DrPH, FAAAAI
DOI : 10.1016/j.jaci.2014.08.002

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